NEST 2

Resident Evil 3 guide · The secret Umbrella laboratory facility

Jill reaches NEST 2 through an underground passage beneath Spencer Memorial Hospital to synthesize a vaccine for the T-Virus. She must retrieve two chemical components, solve a temperature puzzle to complete the vaccine, and restore power to open the facility's blast doors. The zone culminates in consecutive boss battles against Nemesis's mutated forms before Jill escapes the city via helicopter.

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Flash Grenade: Sitting on a shelf in the Storage room safe room on 1FShotgun Shells: On a crate inside the Workers' Break Room on 2FAcid Rounds: On an industrial cart in Lab 1 on 2FFirst Aid Spray: On the desk right next to the final typewriter before entering the Workers' Break Room boss arena

Items

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Override Key: Found inside a terminal console in the Incubation Lab on 2FVaccine Base: Extracted from the synthesis machine in the Incubation Lab after using the Override KeyCulture Sample: Located inside a cold storage vault in Lab 1 on 2FVaccine: Synthesized at the console in the Storage room safe room by combining the Culture Sample and Vaccine Base

Secrets

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Charlie Doll 19 | In the corner of the small balcony walkway outside Lab 1 on 2F | missable: yesCharlie Doll 20 | Tucked behind a large piece of industrial equipment in the room directly behind the final boss arena | missable: yes

Enemies

Zombie

Weak to Head

Found patrolling hallways, with some lying dormant on the floor until approached

Pale Head

Weak to Heavy weapon fire (Magnum, Grenade Launcher)

Rapidly regenerates health unless blown apart with high burst damage

Hunter Beta

Weak to Exposed face/head

Attacks aggressively with leaping slashes and can perform an instant-kill neck swipe

Nemesis (Stage 2)

Weak to Heart chest weak point

Fought in a circular arena where Jill must shoot him off the perimeter walls with assistance from Carlos

Nemesis (Stage 3)

Weak to Glowing pustules across its mass

Massive wall-bound form requiring the use of the FINGeR railgun to destroy

Tips

For the vaccine synthesis console puzzle, set the three temperature chambers to Mid, High, and Low to successfully complete the sequence.
During the final Nemesis encounter, use a weapon with high precision like the Handgun or Shotgun to burst all the glowing red pustules, which stuns Nemesis long enough to safely push the red power cores back into the wall.

Not listed for this area: shops and people.

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Underground Storage

NEST 2 (Lab 1)

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