Prologue

Devil May Cry 5 guide · Nero faces Urizen and loses his arm

Nero rushes through the interior of the Qliphoth tree to assist Dante, who is already locked in combat with the demon king Urizen. After fighting past an introductory group of basic demons, Nero confronts Urizen, only to be effortlessly overpowered and forced to retreat by V. Players must navigate a short, linear corridor to reach and attempt the scripted boss encounter against Urizen.

Achievements here

Fall from GraceComplete the Prologue mission by playing through it normally.

Well I'll Be DamnedDefeat the boss Urizen during the Prologue (or Mission 08) to trigger the alternate early ending.

Achievement guide and roadmap →

Secrets

0/1

Defeating Urizen in the Prologue triggers a secret "premature" victory cutscene, rolls the credits early, and unlocks the next game difficulty mode immediately.

Enemies

Empusa

Basic insectoid demon that moves slowly and serves as introductory combat practice.

Urizen

Powerful boss protected by a red crystal shield; defeating him here unlocks an alternate early ending.

Tips

You do not have the Devil Breakers or your full moveset yet, so rely on continuous Blue Rose charged shots and Red Queen Exceed strikes to deal maximum damage.
When fighting Urizen, keep moving laterally to avoid his sweeping laser and ground-eruption fireballs while focusing damage entirely on his red crystal shield.

Not listed for this area: items, shops and people.

Mission 01: Nero

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