Mission 02: Qliphoth

Devil May Cry 5 guide · Nero searches for Dante and encounters V

Nero navigates the demon-infested streets of Red Grave City toward the towering Qliphoth roots. He battles his way through ruined urban areas and buildings using the newly acquired Overture Devil Breaker. The mission culminates in an arena battle against the parasitic demon Goliath.

Don't miss 0/4

Gold Orb: On top of a ruined canopy outdoors early in the street sectionBlue Orb Fragment: Hidden in an upper room above the blocked corridor in the hotel sectionBlue Orb Fragment inside a ruined bedroom; if you do not destroy the Qliphoth root with the Nidhogg Hatchling and check the floor above through the broken ceiling, you will miss it.Secret Mission 01 can be easily missed if you do not turn around to align the runic wall patterns after acquiring the second Nidhogg Hatchling inside the hotel.

Secrets

0/1

Secret Mission 01 | Located in the hotel hallway; stand near the bed and align the graffiti markings on the wall and pillars with your camera | Eliminate all demons within the time limit

Enemies

Empusa

Standard insectoid worker demon that attacks primarily with forward swipes

Green Empusa

Winged variant that stores blood to heal other demons and should be prioritized

Hell Caina

Scythe-wielding demon that can execute slow, wide-reaching melee slashes

Goliath

Large boss demon that attacks with heavy punches, leaps, and a vacuum attack from its torso stomach

Shops and people

Nico's Van / Divinity Statue: Sells Devil Breakers, character skills, abilities, and consumable orbs

Tips

When Goliath uses his vacuum move to inhale debris, use the Overture or wire snatch to pull yourself away, or fire your gun repeatedly while keeping your distance.
You can call Nico from public payphones located across the stage to access the shop and restock Devil Breakers mid-mission.

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Mission 01: Nero

Mission 03: Flying Hunter

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