Mission 10: Awaken

Devil May Cry 5 guide · Dante infiltrates the Qliphoth to reach Urizen

Dante wakes up from his month-long coma after the prologue and enters the Qliphoth roots to track down Urizen. You play as Dante, getting reacquainted with his four styles, Rebellion, Balrog, and the Ebony & Ivory and Coyote-A firearms. The objective is to fight through flesh-walled corridors and timed door arenas to reach the deepest chamber.

Don't miss 0/3

Blue Orb Fragment: Found behind a timed tooth-gate early in the mission; defeat enemies quickly to sprint through before it seals shutPurple Orb Fragment: In a side passage guarded by Hell Antenoras, off the main path through an organic archwaySecret Mission 07, which requires standing in a specific spot while looking back toward a glowing glyph before the timed door closes off the pathway.

Secrets

0/1

Secret Mission 07 | Located in an upper chamber above a timed gate; look through the entrance archway to align the red runic glyphs on the walls | missable: yes

Enemies

Empusa

Weak standard demon that gathers blood; useful for building up early style rankings.

Hell Caina

Scythe-wielding fodder enemy; easy to stagger using Balrog or Rebellion combos.

Hell Antenora

Berserker demon wielding dual cleavers; enters an uninterruptible hyper-armor charge when knocked down.

Chaos

Lizard-like demon covered in rotating spikes; break its outer spin with heavy gunfire or high-impact attacks before engaging directly.

Urizen

Mission boss shielded by the Yamato crystal; attack the crystal directly while dodging lasers and ground tentacles until a cutscene triggers.

Shops and people

Divinity Statue: Sells weapon skills, style upgrades, and consumable orbs

Tips

Use Dante's Trickster style to rapidly close the distance when fighting to clear rooms before the timed fleshy gates seal shut.
Switching Balrog to Blow Mode lets you rapidly land light punches to ignite the gauntlets, drastically increasing your damage output against heavy targets like Hell Antenoras.

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Mission 09: Genesis

Mission 11: Reason

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