Mission 09: Genesis

Devil May Cry 5 guide · V fights through the demon-infested ruins

V journeys through the ruins of a subterranean quarry and abandoned crypts to reach the roots of the Qliphoth. He must command Shadow and Griffon to defeat various demon waves while navigating overgrown pathways and breaking Blood Clots to open sealed areas. The mission concludes with a gauntlet of tough demonic encounters rather than a dedicated unique boss fight.

Don't miss 0/5

Blue Orb Fragment: Behind a breakable wall in the opening ruined courtyard, accessible by summoning Nightmare to break the obstructionBlue Orb Fragment: High up inside the catacombs near the cavern exit, reached by platforming across elevated stone pillarsPurple Orb Fragment: In an alcove blocked by overgrown roots near the quarry, cleared by destroying an adjacent Blood ClotSecret Mission 06 can be easily missed if you do not position V on the elevated platform in the catacombs and align the glowing red runes visible across the archway.A Blue Orb Fragment located behind a crumbling wall near the start can be missed if you do not summon Nightmare to smash through the barrier.

Items

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Gold Orb: Found resting on an elevated ledge overlooking the ruined stone archways along the main path

Secrets

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Secret Mission 06: Found in the crypt area by dropping down a hole, clearing the demons, standing near the back wall, and lining up the glowing glyphs painted on the entrance arches.

Enemies

Behemoth

Weak to Its exposed, unarmored rear after its bindings break

Large chained demon that charges wildly once its restraining armor is destroyed.

Nobody

Bizarre multi-eyed fiends that jump unpredictably and wear masks to alter their attack patterns.

Proto Angelo

Weak to Parrying its heavy greatsword swings

Heavily armored demonic knight that leads Scudo Angelos and possesses strong blocking capabilities.

Scudo Angelo

Weak to Flanking around its front-facing shield

Shield-bearing demonic soldiers that fight in formation and protect other demons.

Lusachia

Flying spellcaster that hovers above the arena while charging beam attacks and magical projectiles.

Shops and people

Divinity Statue: Sells purple orb fragments, blue orb fragments, gold orbs, and skill upgrades for V, Griffon, and Shadow

Tips

When fighting large crowds or heavy enemies like Behemoths, summon Nightmare not just for offense, but to instantly revive Shadow and Griffon if they enter a stalemated state.
Ride Nightmare by unlocking the Promotion ability to stay completely invulnerable to enemy attacks while dealing direct damage.

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Mission 08: Demon King

Mission 10: Awaken

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