All missables in Devil May Cry 5
Everything you can permanently miss, in the order you reach it: where it is, how to get it and what locks it out.
| Item | Area | Where and how | What locks it out | |
|---|---|---|---|---|
| Blue Orb Fragment | Mission 01: Nero | Underneath the collapsed bridge section just before dropping into the boss arena; turn around and look under the ledgeExact spot: being checked | Being checked | |
| Gold Orb | Mission 02: Qliphoth | On top of a ruined canopy outdoors early in the street sectionExact spot: being checked | Being checked | |
| Blue Orb Fragment | Mission 02: Qliphoth | Hidden in an upper room above the blocked corridor in the hotel sectionExact spot: being checked | Being checked | |
| Blue Orb Fragment | Mission 03: Flying Hunter | Found on a high rooftop across from the starting area by jumping across floating Grim Grips | Being checked | |
| Blue Orb Fragment | Mission 03: Flying Hunter | Hidden inside the interior stairwell shaft; break the Blood Clot and jump down to a hidden alcoveExact spot: being checked | Being checked | |
| Gold Orb | Mission 03: Flying Hunter | Located inside the sewers on a broken overhead walkwayExact spot: being checked | Being checked | |
| Nidhogg Hatchling | Mission 04: V | From the street with the mural, head down the side alley | Being checked | |
| Blue Orb Fragment | Mission 04: V | Inside the warehouse revealed after Nightmare smashes through the wallExact spot: being checked | Being checked | |
| Blue Orb Fragment | Mission 04: V | Past a second Nidhogg barrier opened using the optional hatchlingExact spot: being checked | Being checked | |
| Gold Orb | Mission 04: V | Found across the crumbling highway bridge sectionExact spot: being checked | Being checked | |
| Gold Orb | Mission 05: The Devil Sword Sparda | Found across a raised container platform in the shipyard areaExact spot: being checked | Being checked | |
| Blue Orb Fragment | Mission 05: The Devil Sword Sparda | Inside a hidden side area in the warehouse accessible after destroying a blood clotExact spot: being checked | Being checked | |
| Purple Orb Fragment | Mission 05: The Devil Sword Sparda | Resting near a cluster of shipping containers along the main pathExact spot: being checked | Being checked | |
| Blue Orb Fragment | Mission 06: Steel Impact | High up inside the shipping container structure during the fight areaExact spot: being checked | Being checked | |
| Gold Orb | Mission 06: Steel Impact | Found across elevated metal beams during the pursuitExact spot: being checked | Being checked | |
| Blue Orb Fragment | Mission 07: United Front | On a high ledge above the subway tunnel tracks accessible via platformsExact spot: being checked | Being checked | |
| Blue Orb Fragment | Mission 07: United Front | Behind an elevator shaft wall in the building section, acquired by destroying a Red Orb clump | Being checked | |
| Gold Orb | Mission 07: United Front | Found resting on an elevated platform in the destructible floor area | Being checked | |
| Blue Orb Fragment | Mission 08: Demon King | Found near the start of the mission on a high ledge guarded by enemies, accessible via double jumping or Wire SnatchExact spot: being checked | Being checked | |
| Blue Orb Fragment | Mission 08: Demon King | Rewarded upon defeating the Baphomet enemy during the ascent on the lava platform sectionExact spot: being checked | Being checked | |
| Gold Orb | Mission 08: Demon King | Found off the main path near the ruins of an ancient underground structureExact spot: being checked | Being checked | |
| Blue Orb Fragment | Mission 09: Genesis | Behind a breakable wall in the opening ruined courtyard, accessible by summoning Nightmare to break the obstruction | Being checked | |
| Blue Orb Fragment | Mission 09: Genesis | High up inside the catacombs near the cavern exit, reached by platforming across elevated stone pillarsExact spot: being checked | Being checked | |
| Purple Orb Fragment | Mission 09: Genesis | In an alcove blocked by overgrown roots near the quarry, cleared by destroying an adjacent Blood ClotExact spot: being checked | Being checked | |
| Blue Orb Fragment | Mission 10: Awaken | Found behind a timed tooth-gate early in the mission; defeat enemies quickly to sprint through before it seals shut | Being checked | |
| Purple Orb Fragment | Mission 10: Awaken | In a side passage guarded by Hell Antenoras, off the main path through an organic archwayExact spot: being checked | Being checked | |
| Kalina Ann | Mission 11: Reason | Inside a hidden room accessed by dropping down rubble cleared by destroying the first blood clotExact spot: being checked | Being checked | |
| Blue Orb Fragment | Mission 11: Reason | Earned by successfully completing Secret Mission 08Exact spot: being checked | Being checked | |
| Gold Orb | Mission 12: Yamato | Found behind a wall accessible by double jumping through a hole in the ceiling near the first blood sac | Being checked | |
| Blue Orb Fragment | Mission 12: Yamato | On a high ledge above the central courtyard area that requires using Trickster or Cavaliere to reachExact spot: being checked | Being checked | |
| Purple Orb Fragment | Mission 12: Yamato | In a hidden side passage behind where the second blood sac is destroyed | Being checked | |
| Blue Orb Fragment | Mission 14: Diverging Point: V | Near the exit portal after defeating the first mirage boss, hidden behind a rock formation | Being checked | |
| Blue Orb Fragment | Mission 14: Diverging Point: V | In the descent after reclaiming all familiars, break a Blood Sac and ride the collapsing root upwardExact spot: being checked | Being checked | |
| Purple Orb Fragment | Mission 14: Diverging Point: V | In the area unlocked after destroying the second Blood Sac, tucked in an alcove near Secret Mission 10Exact spot: being checked | Being checked | |
| Blue Orb Fragment | Mission 15: Diverging Point: Nero | High atop a cliff reached by riding Punch Line across a steep ascending chasmExact spot: being checked | Being checked | |
| Blue Orb Fragment | Mission 15: Diverging Point: Nero | Hidden near the bottom of the cavern drop behind a destructible Blood Clot path | Being checked | |
| Blue Orb Fragment | Mission 16: Diverging Point: Dante | Located in a hidden side tunnel accessible during the descent down the deep rocky shaftExact spot: being checked | Being checked | |
| Purple Orb Fragment | Mission 16: Diverging Point: Dante | Resting on a secluded ledge during the drop sequence through the crumbling Qliphoth chambersExact spot: being checked | Being checked | |
| Blue Orb Fragment | Mission 18: Awakening | on an elevated platform above the ruins after clearing the first blood clotExact spot: being checked | Being checked |
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