All missables in Resident Evil 2
Everything you can permanently miss, in the order you reach it: where it is, how to get it and what locks it out.
| Item | Area | Where and how | What locks it out | |
|---|---|---|---|---|
| Handgun Ammo | Gas Station | In the cash register area near the front entrance | Being checked | |
| Tom's Diary | Orphanage | On the table in the hallway outside Sherry's bedroomExact spot: being checked | Being checked | |
| Oliver's Diary | Orphanage | In the upper-floor nursery room | Being checked | |
| Sally's Diary | Orphanage | In the main lobby of the Orphanage on a benchExact spot: being checked | Being checked | |
| Chief's Diary | Orphanage | On the desk inside the Director's RoomExact spot: being checked | Being checked | |
| Letter from the Director | Orphanage | In the Director's Room bathroom during Claire's sectionExact spot: being checked | Being checked | |
| T-Bar Valve Handle | Sewers | Treatment Pool Room, sitting on a work desk near the railingExact spot: being checked | Being checked | |
| Sewer Key | Sewers | Hanging on a key board near the bottom of the ladder in the Bottom WaterwayExact spot: being checked | Being checked | |
| Queen Plug | Sewers | Plugged into an electrical panel in the Supplies Storage RoomExact spot: being checked | Being checked | |
| King Plug | Sewers | Inserted into a socket on the upper level of the Supplies Storage RoomExact spot: being checked | Being checked | |
| Rook Plug | Sewers | In an electrical panel along the wall outside the Workroom, reachable using the lift from the Lower WaterwayExact spot: being checked | Being checked | |
| SLS 60 Reinforced Frame | Sewers | Inside a locked safe in the Treatment Pool Room (combination: Left 2, Right 12, Left 8) | Being checked | |
| Spark Shot | Sewers | Locked behind a gated rack inside the Supplies Storage Room, requiring the King and Queen plugs to access | Being checked | |
| Blue Herb | Sewers (Middle) | On the Cable Car Platform, near the railing beside the stairs leading up to the Monitor Room | Being checked | |
| Handgun Ammo | Sewers (Middle) | Inside the Monitor Room on a small tableExact spot: being checked | Being checked | |
| High-Grade Gunpowder (Yellow) | Sewers (Middle) | In the Monitor Room on a desk (Leon's campaign)Exact spot: being checked | Being checked | |
| High-Grade Gunpowder (White) | Sewers (Middle) | In the Monitor Room on a desk (Claire's campaign)Exact spot: being checked | Being checked |
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