All bosses and key fights in BioShock Infinite
Every key fight, in the order you reach it: what to watch for, what it is weak to and what it drops.
| Fight | Area | Watch for | Weaknesses and resistances | Rewards |
|---|---|---|---|---|
| The Fireman Encounter | Chapter 3 - Raffle Square | The Fireman throws explosive fireballs and rushes Booker, while the turret lays down continuous rapid fire | Barrels packed with firecrackers and headshots deal heavy burst damage | Devil's Kiss vigor |
| Zealot of the Lady Encounter | Chapter 4 - Comstock Center Rooftops | Teleports into an invulnerable swarm of crows, repositions swiftly, and performs aggressive melee lunges with a blade | Immune to damage while flying as birds; susceptible to Devil's Kiss fire traps when solidifying | Murder of Crows Vigor |
| Courtyard Ambush | Chapter 11 - Hall of Heroes Gift Shop | Heavy suppressing fire from Crank Guns, high-damage incendiary blasts from Firemen, and veterans lobbing grenades from upper balconies | Access to the inner back rooms, discarded Crank Guns, and the Shock Jockey vigor | |
| Defense of the Aerodrome Gondola | Chapter 12 - Return to Hall of Heroes | Beasts fire damaging rockets while gunboats deploy flanking troops | Progression to the First Lady airship and access to the interior Infusion | |
| Plaza Ambush Handyman | Chapter 17 - Plaza of Zeal | The Handyman leaps across the plaza, executes ground slams, and electrifies freight rails | Aim directly for the exposed heart on its chest; susceptible to Murder of Crows to momentarily stall him | A piece of Gear dropped on death |
| Jeremiah Fink's Theater Audition | Chapter 18 - The Good Time Club | Sustained crank gun suppression, flame barrages, and flanking crowds across multi-wave assaults | Vulnerable back engine on Patriots; turrets and flying machines are easily compromised | Unlocks access to the backstage dressing room, lower detention chambers, and the dropped crank guns |
| Zeppelin Assault | Chapter 26 - Factory Courtyard | Fires barrages of explosive rockets onto the courtyard gate below; close-range suppression gunfire from the Patriot inside | Opens the path into Fink's factory plant | |
| Factory Courtyard Vox Ambush | Chapter 27 - The Factory | Heavy explosives, sustained Gatling fire, and high-mobility melee charges from the Handyman | Mechanical back weak point on the Patriot; exposed heart on the Handyman; electric vulnerability to Shock Jockey | Drops a piece of Gear from the Handyman and unlocks access to the First Lady docking deck |
| Lady Comstock Crypt Confrontation | Chapter 31 - Memorial Gardens | The Siren remains airborne, screams to shock Booker, and resurrects deceased soldiers with firearms, creating an endless wave of infantry | Progresses the story and reveals the trail of footprints toward the three tears | |
| Sky-Line Clearance Siege | Chapter 37 - Hangar Deck | High-volume suppression fire from Crank Guns, explosive Volley Gun bombardment, and enclosed barge drop-offs | Back gear vulnerability on Motorized Patriots; human Vox susceptible to crowd-control Vigors and environmental tosses | Clears the Sky-Line track, granting passage to the airship's upper levels |
| Engineering Bay Ambush | Chapter 38 - Engineering Deck | Aggressive melee rushdowns, heavy ballistic fire, and area electric shocks from the Handyman | Mechanical heart exposed on chest for critical strikes; vulnerable to Murder of Crows distraction | Gear drop from the Handyman |
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